2-Aminopurine selectively inhibits splicing of tumor necrosis factor alpha mRNA
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چکیده
منابع مشابه
Evaluation of Tumor Necrosis Factor Alpha Polymorphism Frequencies in Endometriosis
Background The pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF-α), is a pathogenic element for a number of disorders. Previous studies have reported that the -1031 T/C and -238 G/A polymorphisms in the promoter region of the TNF-α gene are important factors in reproductive-related disorders. One of the most common gynecological diseases of women during the reproductive years is endo...
متن کاملInhibition of tumor necrosis factor-alpha through selective blockade of Pre-mRNA splicing by shikonin.
We previously developed a gene-gun-based in vivo screening system and identified shikonin as a potent suppressor of tumor necrosis factor-alpha (TNF-alpha) gene expression. Here, we show that shikonin selectively inhibits the expression of TNF-alpha at the RNA splicing level. Treatment of lipopolysaccharide-stimulated human primary monocytes and THP-1 cells with shikonin resulted in normal tran...
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Thalidomide selectively inhibits the production of human monocyte tumor necrosis factor alpha (TNF-alpha) when these cells are triggered with lipopolysaccharide and other agonists in culture. 40% inhibition occurs at the clinically achievable dose of the drug of 1 micrograms/ml. In contrast, the amount of total protein and individual proteins labeled with [35S]methionine and expressed on SDS-PA...
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Tumor necrosis factor-alpha (TNF-alpha) decreased the expression of pulmonary surfactant proteins SP-A and SP-B in human pulmonary adenocarcinoma cell lines. The effect of TNF alpha on SP-A content and mRNA in the pulmonary adenocarcinoma cell line, H441-4, was concentration and time dependent. TNF alpha decreased the cellular content of SP-A to less than 10% of control 48 h after addition. TNF...
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1 CYSTIC FIBROSIS AIRWAY EPITHELIAL CELLS. 2 3 Running title: Azithromycin reduces TNF-α in cystic fibrosis cells. 4 Cristina Cigana, Baroukh Maurice Assael and Paola Melotti* 5 Cystic Fibrosis Center, Azienda Ospedaliera di Verona, Verona, ITALY. 6 7 *Corresponding author. Mailing address: Cystic Fibrosis Center Azienda Ospedaliera di 8 Verona, piazzale Stefani, 1 37126 Verona, Italy. Phone: +...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1996
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.16.6.2814